ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium leak channel NALCN

Intramolecular
Cysteine 1046 and cysteine 1057
Cysteine 207 and cysteine 239
Cysteine 229 and cysteine 245
Cysteine 1405 and cysteine 1417
Cysteine 239 and cysteine 245
Cysteine 229 and cysteine 239
Cysteine 207 and cysteine 229
Cysteine 207 and cysteine 245
Cysteine 376 and cysteine 439
Cysteine 900 and cysteine 1348
More...
Cysteine 898 and cysteine 900
Cysteine 990 and cysteine 1348
Cysteine 900 and cysteine 990
A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 1046 and 1057.

Details

Redox score ?
85
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6Q760
Residue number A
1046
Residue number B
1057
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 1046 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1057 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 207 and 239.

Details

Redox score ?
84
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF0
Residue number A
207
Residue number B
239
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 207 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 229 and 245.

Details

Redox score ?
81
PDB code
7cm3
Structure name
cryo-em structure of human nalcn in complex with fam155a
Structure deposition date
2020-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF0
Residue number A
229
Residue number B
245
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 229 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 1405 and 1417.

Details

Redox score ?
80
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6Q760
Residue number A
1405
Residue number B
1417
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 1405 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1417 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 239 and 245.

Details

Redox score ?
75
PDB code
7cm3
Structure name
cryo-em structure of human nalcn in complex with fam155a
Structure deposition date
2020-07-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF0
Residue number A
239
Residue number B
245
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 239 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 229 and 239.

Details

Redox score ?
75
PDB code
7cu3
Structure name
structure of mammalian nalcn-fam155a complex at 2
Structure deposition date
2020-08-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6Q760
Residue number A
229
Residue number B
239
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 229 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 207 and 229.

Details

Redox score ?
72
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF0
Residue number A
207
Residue number B
229
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 207 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 207 and 245.

Details

Redox score ?
64
PDB code
7cm3
Structure name
cryo-em structure of human nalcn in complex with fam155a
Structure deposition date
2020-07-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF0
Residue number A
207
Residue number B
245
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 207 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 376 and 439. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7cm3
Structure name
cryo-em structure of human nalcn in complex with fam155a
Structure deposition date
2020-07-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
Q8IZF0
Residue number A
376
Residue number B
439
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 376 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 439 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 900 and 1348. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7cu3
Structure name
structure of mammalian nalcn-fam155a complex at 2
Structure deposition date
2020-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
99
Peptide accession
Q6Q760
Residue number A
900
Residue number B
1348
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 900 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1348 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 898 and 900. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
56
Peptide accession
Q8IZF0
Residue number A
898
Residue number B
900
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 898 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 900 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 990 and 1348. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
100
Peptide accession
Q8IZF0
Residue number A
990
Residue number B
1348
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 990 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1348 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium leak channel NALCN between cysteines 900 and 990. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
98
Peptide accession
Q8IZF0
Residue number A
900
Residue number B
990
Peptide name
Sodium leak channel NALCN

Ligandability

Cysteine 900 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 990 of Sodium leak channel NALCN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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