ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Adhesion G-protein coupled receptor G5

Intramolecular
Cysteine 314 and cysteine 404
Cysteine 504 and cysteine 508
Cysteine 384 and cysteine 404
Cysteine 314 and cysteine 384
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G5 between cysteines 314 and 404.

Details

Redox score ?
83
PDB code
7eq1
Structure name
gpr114-gs-scfv16 complex
Structure deposition date
2021-04-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF4
Residue number A
314
Residue number B
404
Peptide name
Adhesion G-protein coupled receptor G5

Ligandability

Cysteine 314 of Adhesion G-protein coupled receptor G5

Cysteine 404 of Adhesion G-protein coupled receptor G5

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G5 between cysteines 504 and 508.

Details

Redox score ?
64
PDB code
7eq1
Structure name
gpr114-gs-scfv16 complex
Structure deposition date
2021-04-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
9
Peptide accession
Q8IZF4
Residue number A
504
Residue number B
508
Peptide name
Adhesion G-protein coupled receptor G5

Ligandability

Cysteine 504 of Adhesion G-protein coupled receptor G5

Cysteine 508 of Adhesion G-protein coupled receptor G5

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G5 between cysteines 384 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7eq1
Structure name
gpr114-gs-scfv16 complex
Structure deposition date
2021-04-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IZF4
Residue number A
384
Residue number B
404
Peptide name
Adhesion G-protein coupled receptor G5

Ligandability

Cysteine 384 of Adhesion G-protein coupled receptor G5

Cysteine 404 of Adhesion G-protein coupled receptor G5

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G5 between cysteines 314 and 384. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7eq1
Structure name
gpr114-gs-scfv16 complex
Structure deposition date
2021-04-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IZF4
Residue number A
314
Residue number B
384
Peptide name
Adhesion G-protein coupled receptor G5

Ligandability

Cysteine 314 of Adhesion G-protein coupled receptor G5

Cysteine 384 of Adhesion G-protein coupled receptor G5

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