ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adhesion G-protein coupled receptor G4

Intramolecular
Cysteine 200 and cysteine 228
Cysteine 58 and cysteine 123
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G4 between cysteines 200 and 228.

Details

Redox score ?
86
PDB code
8b55
Structure name
human adgrg4 ptx-like domain
Structure deposition date
2022-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF6
Residue number A
200
Residue number B
228
Peptide name
Adhesion G-protein coupled receptor G4

Ligandability

Cysteine 200 of Adhesion G-protein coupled receptor G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Adhesion G-protein coupled receptor G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G4 between cysteines 58 and 123.

Details

Redox score ?
80
PDB code
8b55
Structure name
human adgrg4 ptx-like domain
Structure deposition date
2022-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZF6
Residue number A
58
Residue number B
123
Peptide name
Adhesion G-protein coupled receptor G4

Ligandability

Cysteine 58 of Adhesion G-protein coupled receptor G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Adhesion G-protein coupled receptor G4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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