ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon lambda-3

Intermolecular
Cysteine 69 and cysteine 69
Intramolecular
Cysteine 37 and cysteine 136
Cysteine 188 and cysteine 195
Cysteine 71 and cysteine 169
Cysteine 69 and cysteine 169
Cysteine 69 and cysteine 71
A redox-regulated disulphide may form between two units of Interferon lambda-3 at cysteines 69 and 69 (36 and 36 respectively in this structure).

Details

Redox score ?
75
PDB code
3hhc
Structure name
interferon-lambda is functionally an interferon but structurally related to the il-10 family
Structure deposition date
2009-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
0
Peptide A name
Interferon lambda-3
Peptide B name
Interferon lambda-3
Peptide A accession
Q8IZI9
Peptide B accession
Q8IZI9
Peptide A residue number
69
Peptide B residue number
69

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda-3 between cysteines 37 and 136 (4 and 103 respectively in this structure).

Details

Redox score ?
88
PDB code
3hhc
Structure name
interferon-lambda is functionally an interferon but structurally related to the il-10 family
Structure deposition date
2009-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZI9
Residue number A
37
Residue number B
136
Peptide name
Interferon lambda-3

Ligandability

Cysteine 37 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda-3 between cysteines 188 and 195 (155 and 162 respectively in this structure).

Details

Redox score ?
84
PDB code
3hhc
Structure name
interferon-lambda is functionally an interferon but structurally related to the il-10 family
Structure deposition date
2009-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZI9
Residue number A
188
Residue number B
195
Peptide name
Interferon lambda-3

Ligandability

Cysteine 188 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda-3 between cysteines 71 and 169 (38 and 136 respectively in this structure).

Details

Redox score ?
84
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZI9
Residue number A
71
Residue number B
169
Peptide name
Interferon lambda-3

Ligandability

Cysteine 71 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda-3 between cysteines 69 and 169 (36 and 136 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8IZI9
Residue number A
69
Residue number B
169
Peptide name
Interferon lambda-3

Ligandability

Cysteine 69 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda-3 between cysteines 69 and 71 (36 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8IZI9
Residue number A
69
Residue number B
71
Peptide name
Interferon lambda-3

Ligandability

Cysteine 69 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Interferon lambda-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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