ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Netrin receptor UNC5B

Intramolecular
Cysteine 273 and cysteine 285
Cysteine 258 and cysteine 295
Cysteine 69 and cysteine 130
Cysteine 174 and cysteine 225
Cysteine 81 and cysteine 128
Cysteine 262 and cysteine 945
Cysteine 661 and cysteine 663
Cysteine 663 and cysteine 670
Cysteine 716 and cysteine 792
Cysteine 81 and cysteine 130
More...
Cysteine 128 and cysteine 130
Cysteine 551 and cysteine 615
Cysteine 258 and cysteine 262
Cysteine 661 and cysteine 670
A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 273 and 285.

Details

Redox score ?
88
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
273
Residue number B
285
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 273 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 258 and 295.

Details

Redox score ?
87
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
258
Residue number B
295
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 258 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 69 and 130.

Details

Redox score ?
84
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
69
Residue number B
130
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 69 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 174 and 225.

Details

Redox score ?
83
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
174
Residue number B
225
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 174 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 81 and 128.

Details

Redox score ?
82
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
81
Residue number B
128
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 81 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 262 and 945 (262 and 299 respectively in this structure).

Details

Redox score ?
79
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q8K1S3
Residue number A
262
Residue number B
945
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 262 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 945 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 661 and 663.

Details

Redox score ?
69
PDB code
3g5b
Structure name
the structure of unc5b cytoplasmic domain
Structure deposition date
2009-02-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
7
% buried
94
Peptide accession
O08722
Residue number A
661
Residue number B
663
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 661 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 663 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 663 and 670.

Details

Redox score ?
69
PDB code
3g5b
Structure name
the structure of unc5b cytoplasmic domain
Structure deposition date
2009-02-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
7
% buried
100
Peptide accession
O08722
Residue number A
663
Residue number B
670
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 663 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 716 and 792. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3g5b
Structure name
the structure of unc5b cytoplasmic domain
Structure deposition date
2009-02-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
78
Peptide accession
O08722
Residue number A
716
Residue number B
792
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 716 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 792 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 81 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
81
Residue number B
130
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 81 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 128 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K1S3
Residue number A
128
Residue number B
130
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 128 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 551 and 615. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3g5b
Structure name
the structure of unc5b cytoplasmic domain
Structure deposition date
2009-02-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
0
Peptide accession
O08722
Residue number A
551
Residue number B
615
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 551 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 615 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 258 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6ool
Structure name
structural elucidation of the ectodomain of mouse unc5h2
Structure deposition date
2019-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8K1S3
Residue number A
258
Residue number B
262
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 258 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5B between cysteines 661 and 670. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3g5b
Structure name
the structure of unc5b cytoplasmic domain
Structure deposition date
2009-02-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
15
% buried
94
Peptide accession
O08722
Residue number A
661
Residue number B
670
Peptide name
Netrin receptor UNC5B

Ligandability

Cysteine 661 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Netrin receptor UNC5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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