ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mucolipin-2

Intramolecular
Cysteine 164 and cysteine 190
Cysteine 243 and cysteine 274
Cysteine 421 and cysteine 423
A redox-regulated disulphide may form within Mucolipin-2 between cysteines 164 and 190.

Details

Redox score ?
80
PDB code
6hrs
Structure name
structure of the trpml2 eld at ph 4
Structure deposition date
2018-09-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
30
Peptide accession
Q8IZK6
Residue number A
164
Residue number B
190
Peptide name
Mucolipin-2

Ligandability

Cysteine 164 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucolipin-2 between cysteines 243 and 274.

Details

Redox score ?
77
PDB code
6hrs
Structure name
structure of the trpml2 eld at ph 4
Structure deposition date
2018-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
54
Peptide accession
Q8IZK6
Residue number A
243
Residue number B
274
Peptide name
Mucolipin-2

Ligandability

Cysteine 243 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mucolipin-2 between cysteines 421 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7dys
Structure name
cryoem structure of full length mouse trpml2
Structure deposition date
2021-01-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
47
Peptide accession
Q8K595
Residue number A
421
Residue number B
423
Peptide name
Mucolipin-2

Ligandability

Cysteine 421 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Mucolipin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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