ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adhesion G-protein coupled receptor G2

Intramolecular
Cysteine 686 and cysteine 770
Cysteine 661 and cysteine 872
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G2 between cysteines 686 and 770.

Details

Redox score ?
83
PDB code
7wuq
Structure name
tethered peptide activation mechanism of adhesion gpcrs adgrg2 and adgrg4
Structure deposition date
2022-02-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CJ12
Residue number A
686
Residue number B
770
Peptide name
Adhesion G-protein coupled receptor G2

Ligandability

Cysteine 686 of Adhesion G-protein coupled receptor G2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 770 of Adhesion G-protein coupled receptor G2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G2 between cysteines 661 and 872. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7wui
Structure name
tethered peptide activation mechanism of adhesion gpcrs adgrg2 and adgrg4
Structure deposition date
2022-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
86
Peptide accession
Q8CJ12
Residue number A
661
Residue number B
872
Peptide name
Adhesion G-protein coupled receptor G2

Ligandability

Cysteine 661 of Adhesion G-protein coupled receptor G2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 872 of Adhesion G-protein coupled receptor G2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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