WD repeat and FYVE domain-containing protein 3
Intramolecular
Cysteine 3460 and cysteine 3487
Cysteine 3460 and cysteine 3484
Cysteine 3476 and cysteine 3479
Cysteine 3476 and cysteine 3506
Cysteine 3476 and cysteine 3509
Cysteine 3460 and cysteine 3463
Cysteine 3506 and cysteine 3509
Cysteine 3463 and cysteine 3487
Cysteine 3484 and cysteine 3487
Cysteine 3463 and cysteine 3484
More...Cysteine 3479 and cysteine 3506
Cysteine 3479 and cysteine 3509
Cysteine 3460 and cysteine 3506
Cysteine 3487 and cysteine 3506
6w9n A 20 A 47
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3460 and 3487 (20 and 47 respectively in this structure).
Details
Redox score ?
85
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
15
Peptide accession
Q8IZQ1
Residue number A
3460
Residue number B
3487
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3460 of WD repeat and FYVE domain-containing protein 3
Cysteine 3487 of WD repeat and FYVE domain-containing protein 3
6w9n A 20 A 44
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3460 and 3484 (20 and 44 respectively in this structure).
Details
Redox score ?
84
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
12
Peptide accession
Q8IZQ1
Residue number A
3460
Residue number B
3484
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3460 of WD repeat and FYVE domain-containing protein 3
Cysteine 3484 of WD repeat and FYVE domain-containing protein 3
6w9n A 36 A 39
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3476 and 3479 (36 and 39 respectively in this structure).
Details
Redox score ?
84
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
30
Peptide accession
Q8IZQ1
Residue number A
3476
Residue number B
3479
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3476 of WD repeat and FYVE domain-containing protein 3
Cysteine 3479 of WD repeat and FYVE domain-containing protein 3
6w9n A 36 A 66
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3476 and 3506 (36 and 66 respectively in this structure).
Details
Redox score ?
84
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
36
Peptide accession
Q8IZQ1
Residue number A
3476
Residue number B
3506
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3476 of WD repeat and FYVE domain-containing protein 3
Cysteine 3506 of WD repeat and FYVE domain-containing protein 3
6w9n A 36 A 69
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3476 and 3509 (36 and 69 respectively in this structure).
Details
Redox score ?
83
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
33
Peptide accession
Q8IZQ1
Residue number A
3476
Residue number B
3509
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3476 of WD repeat and FYVE domain-containing protein 3
Cysteine 3509 of WD repeat and FYVE domain-containing protein 3
6w9n A 20 A 23
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3460 and 3463 (20 and 23 respectively in this structure).
Details
Redox score ?
83
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
8
Peptide accession
Q8IZQ1
Residue number A
3460
Residue number B
3463
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3460 of WD repeat and FYVE domain-containing protein 3
Cysteine 3463 of WD repeat and FYVE domain-containing protein 3
6w9n A 66 A 69
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3506 and 3509 (66 and 69 respectively in this structure).
Details
Redox score ?
78
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
31
Peptide accession
Q8IZQ1
Residue number A
3506
Residue number B
3509
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3506 of WD repeat and FYVE domain-containing protein 3
Cysteine 3509 of WD repeat and FYVE domain-containing protein 3
6w9n A 23 A 47
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3463 and 3487 (23 and 47 respectively in this structure).
Details
Redox score ?
77
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
8
Peptide accession
Q8IZQ1
Residue number A
3463
Residue number B
3487
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3463 of WD repeat and FYVE domain-containing protein 3
Cysteine 3487 of WD repeat and FYVE domain-containing protein 3
6w9n A 44 A 47
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3484 and 3487 (44 and 47 respectively in this structure).
Details
Redox score ?
76
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
12
Peptide accession
Q8IZQ1
Residue number A
3484
Residue number B
3487
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3484 of WD repeat and FYVE domain-containing protein 3
Cysteine 3487 of WD repeat and FYVE domain-containing protein 3
6w9n A 23 A 44
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3463 and 3484 (23 and 44 respectively in this structure).
Details
Redox score ?
76
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
4
Peptide accession
Q8IZQ1
Residue number A
3463
Residue number B
3484
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3463 of WD repeat and FYVE domain-containing protein 3
Cysteine 3484 of WD repeat and FYVE domain-containing protein 3
6w9n A 39 A 66
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3479 and 3506 (39 and 66 respectively in this structure).
Details
Redox score ?
75
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
28
Peptide accession
Q8IZQ1
Residue number A
3479
Residue number B
3506
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3479 of WD repeat and FYVE domain-containing protein 3
Cysteine 3506 of WD repeat and FYVE domain-containing protein 3
6w9n A 39 A 69
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3479 and 3509 (39 and 69 respectively in this structure).
Details
Redox score ?
75
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
26
Peptide accession
Q8IZQ1
Residue number A
3479
Residue number B
3509
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3479 of WD repeat and FYVE domain-containing protein 3
Cysteine 3509 of WD repeat and FYVE domain-containing protein 3
6w9n A 20 A 66
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3460 and 3506 (20 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
24
Peptide accession
Q8IZQ1
Residue number A
3460
Residue number B
3506
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3460 of WD repeat and FYVE domain-containing protein 3
Cysteine 3506 of WD repeat and FYVE domain-containing protein 3
6w9n A 47 A 66
A redox-regulated disulphide may form within WD repeat and FYVE domain-containing protein 3 between cysteines 3487 and 3506 (47 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6w9n
Structure name
solution structure of the fyve domain of alfy
Structure deposition date
2020-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
24
Peptide accession
Q8IZQ1
Residue number A
3487
Residue number B
3506
Peptide name
WD repeat and FYVE domain-containing protein 3
Ligandability
Cysteine 3487 of WD repeat and FYVE domain-containing protein 3
Cysteine 3506 of WD repeat and FYVE domain-containing protein 3
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