ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Heparan sulfate glucosamine 3-O-sulfotransferase 5

Intramolecular
Cysteine 294 and cysteine 304
Cysteine 33 and cysteine 36
A redox-regulated disulphide may form within Heparan sulfate glucosamine 3-O-sulfotransferase 5 between cysteines 294 and 304.

Details

Redox score ?
83
PDB code
3bd9
Structure name
human 3-o-sulfotransferase isoform 5 with bound pap
Structure deposition date
2007-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZT8
Residue number A
294
Residue number B
304
Peptide name
Heparan sulfate glucosamine 3-O-sulfotransferase 5

Ligandability

Cysteine 294 of Heparan sulfate glucosamine 3-O-sulfotransferase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Heparan sulfate glucosamine 3-O-sulfotransferase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Heparan sulfate glucosamine 3-O-sulfotransferase 5 between cysteines 33 and 36.

Details

Redox score ?
nan
PDB code
7scd
Structure name
ternary complex of fixed-arm trx-3ost5 (i299e) with 8mer-1 octasaccharide substrate and co-factor product pap
Structure deposition date
2021-09-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IZT8
Residue number A
33
Residue number B
36
Peptide name
Heparan sulfate glucosamine 3-O-sulfotransferase 5

Ligandability

Cysteine 33 of Heparan sulfate glucosamine 3-O-sulfotransferase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Heparan sulfate glucosamine 3-O-sulfotransferase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 in protein A could not be asigned to a Uniprot residue.
Cysteine 36 in protein B could not be asigned to a Uniprot residue.
If this tool was useful for finding a disulphide, please cite: