ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Paired immunoglobulin-like receptor B

Intramolecular
Cysteine 144 and cysteine 197
Cysteine 444 and cysteine 495
Cysteine 49 and cysteine 98
Cysteine 343 and cysteine 395
Cysteine 544 and cysteine 595
Cysteine 246 and cysteine 295
Cysteine 246 and cysteine 297
Cysteine 295 and cysteine 297
Cysteine 195 and cysteine 197
A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 144 and 197.

Details

Redox score ?
81
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
144
Residue number B
197
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 144 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 444 and 495.

Details

Redox score ?
81
PDB code
6grt
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
444
Residue number B
495
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 444 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 495 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 49 and 98.

Details

Redox score ?
81
PDB code
6grt
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
49
Residue number B
98
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 49 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 343 and 395.

Details

Redox score ?
80
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
343
Residue number B
395
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 343 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 395 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 544 and 595.

Details

Redox score ?
79
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
544
Residue number B
595
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 544 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 246 and 295.

Details

Redox score ?
79
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K4V6
Residue number A
246
Residue number B
295
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 246 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 246 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6grq
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
10
% buried
nan
Peptide accession
Q8K4V6
Residue number A
246
Residue number B
297
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 246 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 295 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8K4V6
Residue number A
295
Residue number B
297
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 295 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Paired immunoglobulin-like receptor B between cysteines 195 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6grs
Structure name
paired immunoglobulin-like receptor b (pirb) or leukocyte immunoglobulin-like receptor subfamily b member 3 (lilrb3) full extracellular domain
Structure deposition date
2018-06-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
nan
Peptide accession
Q8K4V6
Residue number A
195
Residue number B
197
Peptide name
Paired immunoglobulin-like receptor B

Ligandability

Cysteine 195 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Paired immunoglobulin-like receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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