ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuroligin-4, X-linked

Intramolecular
Cysteine 476 and cysteine 510
Cysteine 306 and cysteine 317
Cysteine 110 and cysteine 146
A redox-regulated disulphide may form within Neuroligin-4, X-linked between cysteines 476 and 510.

Details

Redox score ?
84
PDB code
3be8
Structure name
crystal structure of the synaptic protein neuroligin 4
Structure deposition date
2007-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N0W4
Residue number A
476
Residue number B
510
Peptide name
Neuroligin-4, X-linked

Ligandability

Cysteine 476 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-4, X-linked between cysteines 306 and 317.

Details

Redox score ?
83
PDB code
2wqz
Structure name
crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement
Structure deposition date
2009-08-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N0W4
Residue number A
306
Residue number B
317
Peptide name
Neuroligin-4, X-linked

Ligandability

Cysteine 306 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-4, X-linked between cysteines 110 and 146.

Details

Redox score ?
80
PDB code
2xb6
Structure name
revisited crystal structure of neurexin1beta-neuroligin4 complex
Structure deposition date
2010-04-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N0W4
Residue number A
110
Residue number B
146
Peptide name
Neuroligin-4, X-linked

Ligandability

Cysteine 110 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Neuroligin-4, X-linked

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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