Regulatory-associated protein of mTOR
Intramolecular
Cysteine 246 and cysteine 362
Cysteine 562 and cysteine 580
Cysteine 36 and cysteine 1081
Cysteine 279 and cysteine 283 L
Cysteine 553 and cysteine 580
Cysteine 553 and cysteine 562
Cysteine 617 and cysteine 960
Cysteine 36 and cysteine 617
Cysteine 553 and cysteine 594
Cysteine 196 and cysteine 246
More...Cysteine 1037 and cysteine 1047
Cysteine 65 and cysteine 196
7pec E 246 E 362
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 246 and 362.
Details
Redox score ?
74
PDB code
7pec
Structure name
cryo-em structure of deptor bound to human mtor complex 1, dept-bound subset local refinement
Structure deposition date
2021-08-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
82
Peptide accession
Q8N122
Residue number A
246
Residue number B
362
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 246 of Regulatory-associated protein of mTOR
Cysteine 362 of Regulatory-associated protein of mTOR
7pea E 562 E 580
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 562 and 580.
Details
Redox score ?
63
PDB code
7pea
Structure name
cryo-em structure of deptor bound to human mtor complex 1, overall refinement
Structure deposition date
2021-08-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q8N122
Residue number A
562
Residue number B
580
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 562 of Regulatory-associated protein of mTOR
Cysteine 580 of Regulatory-associated protein of mTOR
7ux2 A 36 A 1081
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 36 and 1081. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7ux2
Structure name
cryo-em structure of the raptor-tfeb-rag-ragulator complex
Structure deposition date
2022-05-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
46
Peptide accession
Q8N122
Residue number A
36
Residue number B
1081
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 36 of Regulatory-associated protein of mTOR
Cysteine 1081 of Regulatory-associated protein of mTOR
6u62 A 279 A 283
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 279 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6u62
Structure name
raptor-rag-ragulator complex
Structure deposition date
2019-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
14
Peptide accession
Q8N122
Residue number A
279
Residue number B
283
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 279 of Regulatory-associated protein of mTOR
Cysteine 283 of Regulatory-associated protein of mTOR
7ux2 A 553 A 580
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 553 and 580. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ux2
Structure name
cryo-em structure of the raptor-tfeb-rag-ragulator complex
Structure deposition date
2022-05-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
94
Minimum pKa ?
9
% buried
100
Peptide accession
Q8N122
Residue number A
553
Residue number B
580
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 553 of Regulatory-associated protein of mTOR
Cysteine 580 of Regulatory-associated protein of mTOR
6u62 A 553 A 562
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 553 and 562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6u62
Structure name
raptor-rag-ragulator complex
Structure deposition date
2019-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q8N122
Residue number A
553
Residue number B
562
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 553 of Regulatory-associated protein of mTOR
Cysteine 562 of Regulatory-associated protein of mTOR
7ux2 A 617 A 960
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 617 and 960. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7ux2
Structure name
cryo-em structure of the raptor-tfeb-rag-ragulator complex
Structure deposition date
2022-05-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
Q8N122
Residue number A
617
Residue number B
960
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 617 of Regulatory-associated protein of mTOR
Cysteine 960 of Regulatory-associated protein of mTOR
7owg Y 36 Y 617
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 36 and 617. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7owg
Structure name
human deptor in a complex with mutant human mtorc1 a1459p
Structure deposition date
2021-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
81
Peptide accession
Q8N122
Residue number A
36
Residue number B
617
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 36 of Regulatory-associated protein of mTOR
Cysteine 617 of Regulatory-associated protein of mTOR
7owg Y 553 Y 594
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 553 and 594. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7owg
Structure name
human deptor in a complex with mutant human mtorc1 a1459p
Structure deposition date
2021-06-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
64
Peptide accession
Q8N122
Residue number A
553
Residue number B
594
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 553 of Regulatory-associated protein of mTOR
Cysteine 594 of Regulatory-associated protein of mTOR
7pec E 196 E 246
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 196 and 246. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7pec
Structure name
cryo-em structure of deptor bound to human mtor complex 1, dept-bound subset local refinement
Structure deposition date
2021-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
90
Peptide accession
Q8N122
Residue number A
196
Residue number B
246
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 196 of Regulatory-associated protein of mTOR
Cysteine 246 of Regulatory-associated protein of mTOR
7owg Y 1037 Y 1047
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 1037 and 1047. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
7owg
Structure name
human deptor in a complex with mutant human mtorc1 a1459p
Structure deposition date
2021-06-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
80
Peptide accession
Q8N122
Residue number A
1037
Residue number B
1047
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 1037 of Regulatory-associated protein of mTOR
Cysteine 1047 of Regulatory-associated protein of mTOR
7peb E 65 E 196
A redox-regulated disulphide may form within Regulatory-associated protein of mTOR between cysteines 65 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
22
PDB code
7peb
Structure name
cryo-em structure of deptor bound to human mtor complex 1, focussed on one protomer
Structure deposition date
2021-08-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q8N122
Residue number A
65
Residue number B
196
Peptide name
Regulatory-associated protein of mTOR
Ligandability
Cysteine 65 of Regulatory-associated protein of mTOR
Cysteine 196 of Regulatory-associated protein of mTOR
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