Adenylosuccinate synthetase isozyme 1

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Adenylosuccinate synthetase isozyme 1 at cysteines 281 and 281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

1iwe

Structure name

imp complex of the recombinant mouse-muscle adenylosuccinate synthetase

Structure deposition date

2002-05-04

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Adenylosuccinate synthetase isozyme 1

Peptide B name

Adenylosuccinate synthetase isozyme 1

Peptide A accession

P28650

Peptide B accession

P28650

Peptide A residue number

281

Peptide B residue number

281

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylosuccinate synthetase isozyme 1 between cysteines 63 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

1loo

Structure name

crystal structure of the mouse-muscle adenylosuccinate synthetase ligated with gtp

Structure deposition date

2002-05-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P28650

Residue number A

Residue number B

275

Peptide name

Adenylosuccinate synthetase isozyme 1

Ligandability

Cysteine 63 of Adenylosuccinate synthetase isozyme 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Adenylosuccinate synthetase isozyme 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylosuccinate synthetase isozyme 1 between cysteines 63 and 281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?