ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukocyte immunoglobulin-like receptor subfamily A member 2

Intermolecular
Cysteine 195 and cysteine 143
Cysteine 155 and cysteine 195
Intramolecular
Cysteine 49 and cysteine 97
Cysteine 143 and cysteine 155
A redox-regulated disulphide may form between two units of Leukocyte immunoglobulin-like receptor subfamily A member 2 at cysteines 195 and 143 (172 and 120 respectively in this structure).

Details

Redox score ?
80
PDB code
2otp
Structure name
crystal structure of immunoglobulin-like transcript 1 (ilt1/lir7/lilra2)
Structure deposition date
2007-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide A name
Leukocyte immunoglobulin-like receptor subfamily A member 2
Peptide B name
Leukocyte immunoglobulin-like receptor subfamily A member 2
Peptide A accession
Q8N149
Peptide B accession
Q8N149
Peptide A residue number
195
Peptide B residue number
143

Ligandability

Cysteine 195 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Leukocyte immunoglobulin-like receptor subfamily A member 2 at cysteines 155 and 195 (132 and 172 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2otp
Structure name
crystal structure of immunoglobulin-like transcript 1 (ilt1/lir7/lilra2)
Structure deposition date
2007-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Leukocyte immunoglobulin-like receptor subfamily A member 2
Peptide B name
Leukocyte immunoglobulin-like receptor subfamily A member 2
Peptide A accession
Q8N149
Peptide B accession
Q8N149
Peptide A residue number
155
Peptide B residue number
195

Ligandability

Cysteine 155 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily A member 2 between cysteines 49 and 97 (26 and 74 respectively in this structure).

Details

Redox score ?
83
PDB code
2otp
Structure name
crystal structure of immunoglobulin-like transcript 1 (ilt1/lir7/lilra2)
Structure deposition date
2007-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N149
Residue number A
49
Residue number B
97
Peptide name
Leukocyte immunoglobulin-like receptor subfamily A member 2

Ligandability

Cysteine 49 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily A member 2 between cysteines 143 and 155 (120 and 132 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2otp
Structure name
crystal structure of immunoglobulin-like transcript 1 (ilt1/lir7/lilra2)
Structure deposition date
2007-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N149
Residue number A
143
Residue number B
155
Peptide name
Leukocyte immunoglobulin-like receptor subfamily A member 2

Ligandability

Cysteine 143 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 155 of Leukocyte immunoglobulin-like receptor subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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