ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Nuclear pore complex protein Nup93

Intramolecular
Cysteine 392 and cysteine 397
Cysteine 325 and cysteine 328
Cysteine 209 and cysteine 487
A redox-regulated disulphide may form within Nuclear pore complex protein Nup93 between cysteines 392 and 397.

Details

Redox score ?
79
PDB code
7mw1
Structure name
crystal structure of the homo sapiens nup93-nup53 complex (nup93 residues 174-819; nup53 residues 84-150)
Structure deposition date
2021-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N1F7
Residue number A
392
Residue number B
397
Peptide name
Nuclear pore complex protein Nup93

Ligandability

Cysteine 392 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup93 between cysteines 325 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7mw1
Structure name
crystal structure of the homo sapiens nup93-nup53 complex (nup93 residues 174-819; nup53 residues 84-150)
Structure deposition date
2021-05-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
96
Peptide accession
Q8N1F7
Residue number A
325
Residue number B
328
Peptide name
Nuclear pore complex protein Nup93

Ligandability

Cysteine 325 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup93 between cysteines 209 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7mw0
Structure name
crystal structure of homo sapiens nup93 solenoid (residues 174-819)
Structure deposition date
2021-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
95
Peptide accession
Q8N1F7
Residue number A
209
Residue number B
487
Peptide name
Nuclear pore complex protein Nup93

Ligandability

Cysteine 209 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Nuclear pore complex protein Nup93

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: