ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nesprin-4

Intermolecular
Cysteine 382 and cysteine 382
Cysteine 381 and cysteine 382
A redox-regulated disulphide may form between two units of Nesprin-4 at cysteines 382 and 382.

Details

Redox score ?
88
PDB code
6r16
Structure name
crystal structure of the sun1-kash4 6:6 complex
Structure deposition date
2019-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Nesprin-4
Peptide B name
Nesprin-4
Peptide A accession
Q8N205
Peptide B accession
Q8N205
Peptide A residue number
382
Peptide B residue number
382

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Nesprin-4 at cysteines 381 and 382.

Details

Redox score ?
84
PDB code
6r16
Structure name
crystal structure of the sun1-kash4 6:6 complex
Structure deposition date
2019-03-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
11
Peptide A name
Nesprin-4
Peptide B name
Nesprin-4
Peptide A accession
Q8N205
Peptide B accession
Q8N205
Peptide A residue number
381
Peptide B residue number
382

Ligandability

Cysteine 381 of Nesprin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Nesprin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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