ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitochondrial cardiolipin hydrolase

Intramolecular
Cysteine 66 and cysteine 68
Cysteine 49 and cysteine 66
Cysteine 49 and cysteine 68
A redox-regulated disulphide may form within Mitochondrial cardiolipin hydrolase between cysteines 66 and 68.

Details

Redox score ?
93
PDB code
4ggj
Structure name
crystal structure of zucchini from mouse (mzuc / pld6 / mitopld)
Structure deposition date
2012-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
0
Peptide accession
Q5SWZ9
Residue number A
66
Residue number B
68
Peptide name
Mitochondrial cardiolipin hydrolase

Ligandability

Cysteine 66 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial cardiolipin hydrolase between cysteines 49 and 66.

Details

Redox score ?
89
PDB code
4ggj
Structure name
crystal structure of zucchini from mouse (mzuc / pld6 / mitopld)
Structure deposition date
2012-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
0
Peptide accession
Q5SWZ9
Residue number A
49
Residue number B
66
Peptide name
Mitochondrial cardiolipin hydrolase

Ligandability

Cysteine 49 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial cardiolipin hydrolase between cysteines 49 and 68.

Details

Redox score ?
77
PDB code
4ggk
Structure name
crystal structure of zucchini from mouse (mzuc / pld6 / mitopld) bound to tungstate
Structure deposition date
2012-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SWZ9
Residue number A
49
Residue number B
68
Peptide name
Mitochondrial cardiolipin hydrolase

Ligandability

Cysteine 49 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Mitochondrial cardiolipin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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