ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase 40

Intramolecular
Cysteine 143 and cysteine 145
Cysteine 52 and cysteine 138
A redox-regulated disulphide may form within Serine/threonine-protein kinase 40 between cysteines 143 and 145.

Details

Redox score ?
78
PDB code
5l2q
Structure name
serine/threonine-protein kinase 40 (stk40) kinase homology domain
Structure deposition date
2016-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
4
% buried
66
Peptide accession
Q8N2I9
Residue number A
143
Residue number B
145
Peptide name
Serine/threonine-protein kinase 40

Ligandability

Cysteine 143 of Serine/threonine-protein kinase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Serine/threonine-protein kinase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase 40 between cysteines 52 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5l2q
Structure name
serine/threonine-protein kinase 40 (stk40) kinase homology domain
Structure deposition date
2016-08-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
58
Peptide accession
Q8N2I9
Residue number A
52
Residue number B
138
Peptide name
Serine/threonine-protein kinase 40

Ligandability

Cysteine 52 of Serine/threonine-protein kinase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Serine/threonine-protein kinase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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