ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glycerol-3-phosphate dehydrogenase 1-like protein

Intramolecular
Cysteine 216 and cysteine 221
Cysteine 202 and cysteine 258
Cysteine 202 and cysteine 245
Cysteine 216 and cysteine 343
Cysteine 216 and cysteine 267
A redox-regulated disulphide may form within Glycerol-3-phosphate dehydrogenase 1-like protein between cysteines 216 and 221.

Details

Redox score ?
70
PDB code
2pla
Structure name
crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structure deposition date
2007-04-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
85
Peptide accession
Q8N335
Residue number A
216
Residue number B
221
Peptide name
Glycerol-3-phosphate dehydrogenase 1-like protein

Ligandability

Cysteine 216 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycerol-3-phosphate dehydrogenase 1-like protein between cysteines 202 and 258.

Details

Redox score ?
61
PDB code
2pla
Structure name
crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structure deposition date
2007-04-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
102
Minimum pKa ?
9
% buried
100
Peptide accession
Q8N335
Residue number A
202
Residue number B
258
Peptide name
Glycerol-3-phosphate dehydrogenase 1-like protein

Ligandability

Cysteine 202 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycerol-3-phosphate dehydrogenase 1-like protein between cysteines 202 and 245. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2pla
Structure name
crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structure deposition date
2007-04-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
76
Peptide accession
Q8N335
Residue number A
202
Residue number B
245
Peptide name
Glycerol-3-phosphate dehydrogenase 1-like protein

Ligandability

Cysteine 202 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycerol-3-phosphate dehydrogenase 1-like protein between cysteines 216 and 343. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2pla
Structure name
crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structure deposition date
2007-04-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
88
Peptide accession
Q8N335
Residue number A
216
Residue number B
343
Peptide name
Glycerol-3-phosphate dehydrogenase 1-like protein

Ligandability

Cysteine 216 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycerol-3-phosphate dehydrogenase 1-like protein between cysteines 216 and 267. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
2pla
Structure name
crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structure deposition date
2007-04-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q8N335
Residue number A
216
Residue number B
267
Peptide name
Glycerol-3-phosphate dehydrogenase 1-like protein

Ligandability

Cysteine 216 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of Glycerol-3-phosphate dehydrogenase 1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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