ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Protein phosphatase 1K, mitochondrial

Intramolecular
Cysteine 214 and cysteine 310
Cysteine 138 and cysteine 145
A redox-regulated disulphide may form within Protein phosphatase 1K, mitochondrial between cysteines 214 and 310.

Details

Redox score ?
80
PDB code
6ak7
Structure name
crystal structure of ppm1k-n94k
Structure deposition date
2018-08-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
60
Peptide accession
Q8N3J5
Residue number A
214
Residue number B
310
Peptide name
Protein phosphatase 1K, mitochondrial

Ligandability

Cysteine 214 of Protein phosphatase 1K, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Protein phosphatase 1K, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein phosphatase 1K, mitochondrial between cysteines 138 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4da1
Structure name
crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with mg (ii) ions at the active site
Structure deposition date
2012-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
nan
Peptide accession
Q8N3J5
Residue number A
138
Residue number B
145
Peptide name
Protein phosphatase 1K, mitochondrial

Ligandability

Cysteine 138 of Protein phosphatase 1K, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Protein phosphatase 1K, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: