a tool for identifying drug-targetable redox-active disulphides

F-box/WD repeat-containing protein 8

Intermolecular

Cysteine 139 and cysteine 160 of S-phase kinase-associated protein 1 L

A redox-regulated disulphide may form between cysteine 139 of F-box/WD repeat-containing protein 8 and cysteine 160 of S-phase kinase-associated protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

structure of crl7fbxw8 reveals coupling with cul1-rbx1/roc1 for multi- cullin-ring e3-catalyzed ubiquitin ligation

Structure deposition date

2022-03-17

Thiol separation (Å)

9

Half-sphere exposure sum ?

nan

Minimum pK_a ?

10

% buried

64

Peptide A name

F-box/WD repeat-containing protein 8

Peptide B name

S-phase kinase-associated protein 1

Peptide A accession

Peptide B accession

Peptide A residue number

139

Peptide B residue number

160

Ligandability

Cysteine 139 of F-box/WD repeat-containing protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of S-phase kinase-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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