ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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D-2-hydroxyglutarate dehydrogenase, mitochondrial

Intramolecular
Cysteine 168 and cysteine 172
Cysteine 168 and cysteine 272
A redox-regulated disulphide may form within D-2-hydroxyglutarate dehydrogenase, mitochondrial between cysteines 168 and 172.

Details

Redox score ?
67
PDB code
6lpq
Structure name
crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal)
Structure deposition date
2020-01-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
88
Peptide accession
Q8N465
Residue number A
168
Residue number B
172
Peptide name
D-2-hydroxyglutarate dehydrogenase, mitochondrial

Ligandability

Cysteine 168 of D-2-hydroxyglutarate dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of D-2-hydroxyglutarate dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within D-2-hydroxyglutarate dehydrogenase, mitochondrial between cysteines 168 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6lpq
Structure name
crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal)
Structure deposition date
2020-01-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
93
Peptide accession
Q8N465
Residue number A
168
Residue number B
272
Peptide name
D-2-hydroxyglutarate dehydrogenase, mitochondrial

Ligandability

Cysteine 168 of D-2-hydroxyglutarate dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of D-2-hydroxyglutarate dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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