Calcium homeostasis modulator protein 5
Intermolecular
Cysteine 203 and cysteine 80
Cysteine 203 and cysteine 81
Intramolecular
Cysteine 142 and cysteine 149
Cysteine 43 and cysteine 158
Cysteine 41 and cysteine 127
Cysteine 80 and cysteine 81
Cysteine 41 and cysteine 158
Cysteine 41 and cysteine 43
Cysteine 199 and cysteine 203
Cysteine 185 and cysteine 188
More...Cysteine 43 and cysteine 127
Cysteine 127 and cysteine 158
7d65 D 203 E 80
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 5 at cysteines 203 and 80.
Details
Redox score ?
67
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
34
Peptide A name
Calcium homeostasis modulator protein 5
Peptide B name
Calcium homeostasis modulator protein 5
Peptide A accession
Q8N5C1
Peptide B accession
Q8N5C1
Peptide A residue number
203
Peptide B residue number
80
Ligandability
Cysteine 203 of Calcium homeostasis modulator protein 5
Cysteine 80 of Calcium homeostasis modulator protein 5
7d65 J 203 K 81
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 5 at cysteines 203 and 81.
Details
Redox score ?
66
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
20
Peptide A name
Calcium homeostasis modulator protein 5
Peptide B name
Calcium homeostasis modulator protein 5
Peptide A accession
Q8N5C1
Peptide B accession
Q8N5C1
Peptide A residue number
203
Peptide B residue number
81
Ligandability
Cysteine 203 of Calcium homeostasis modulator protein 5
Cysteine 81 of Calcium homeostasis modulator protein 5
7d60 F 142 F 149
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 142 and 149.
Details
Redox score ?
88
PDB code
7d60
Structure name
cryo-em structure of human calhm5 in the presence of rubidium red
Structure deposition date
2020-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
142
Residue number B
149
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 142 of Calcium homeostasis modulator protein 5
Cysteine 149 of Calcium homeostasis modulator protein 5
7d65 B 43 B 158
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 43 and 158.
Details
Redox score ?
81
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
43
Residue number B
158
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 43 of Calcium homeostasis modulator protein 5
Cysteine 158 of Calcium homeostasis modulator protein 5
7d65 F 41 F 127
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 41 and 127.
Details
Redox score ?
80
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
41
Residue number B
127
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 41 of Calcium homeostasis modulator protein 5
Cysteine 127 of Calcium homeostasis modulator protein 5
7d65 B 80 B 81
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 80 and 81.
Details
Redox score ?
69
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
14
Peptide accession
Q8N5C1
Residue number A
80
Residue number B
81
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 80 of Calcium homeostasis modulator protein 5
Cysteine 81 of Calcium homeostasis modulator protein 5
7d61 H 41 H 158
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 41 and 158.
Details
Redox score ?
61
PDB code
7d61
Structure name
cryo-em structure of human calhm5 in the presence of edta
Structure deposition date
2020-09-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
41
Residue number B
158
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 41 of Calcium homeostasis modulator protein 5
Cysteine 158 of Calcium homeostasis modulator protein 5
7d61 H 41 H 43
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 41 and 43.
Details
Redox score ?
61
PDB code
7d61
Structure name
cryo-em structure of human calhm5 in the presence of edta
Structure deposition date
2020-09-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
41
Residue number B
43
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 41 of Calcium homeostasis modulator protein 5
Cysteine 43 of Calcium homeostasis modulator protein 5
7d61 B 199 B 203
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 199 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7d61
Structure name
cryo-em structure of human calhm5 in the presence of edta
Structure deposition date
2020-09-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
11
% buried
50
Peptide accession
Q8N5C1
Residue number A
199
Residue number B
203
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 199 of Calcium homeostasis modulator protein 5
Cysteine 203 of Calcium homeostasis modulator protein 5
7d65 H 185 H 188
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 185 and 188. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
27
Peptide accession
Q8N5C1
Residue number A
185
Residue number B
188
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 185 of Calcium homeostasis modulator protein 5
Cysteine 188 of Calcium homeostasis modulator protein 5
7d65 I 43 I 127
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 43 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7d65
Structure name
cryo-em structure of human calhm5 in the presence of ca2+
Structure deposition date
2020-09-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
43
Residue number B
127
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 43 of Calcium homeostasis modulator protein 5
Cysteine 127 of Calcium homeostasis modulator protein 5
7d61 D 127 D 158
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 5 between cysteines 127 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7d61
Structure name
cryo-em structure of human calhm5 in the presence of edta
Structure deposition date
2020-09-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5C1
Residue number A
127
Residue number B
158
Peptide name
Calcium homeostasis modulator protein 5
Ligandability
Cysteine 127 of Calcium homeostasis modulator protein 5
Cysteine 158 of Calcium homeostasis modulator protein 5
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