ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Intramolecular
Cysteine 693 and cysteine 707
Cysteine 696 and cysteine 707
Cysteine 707 and cysteine 710
Cysteine 693 and cysteine 710
Cysteine 693 and cysteine 696
Cysteine 696 and cysteine 710
A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 693 and 707.

Details

Redox score ?
89
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
3
% buried
48
Peptide accession
Q571K4
Residue number A
693
Residue number B
707
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 693 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 707 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 696 and 707.

Details

Redox score ?
87
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
3
% buried
59
Peptide accession
Q571K4
Residue number A
696
Residue number B
707
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 696 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 707 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 707 and 710.

Details

Redox score ?
87
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
3
% buried
47
Peptide accession
Q571K4
Residue number A
707
Residue number B
710
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 707 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 710 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 693 and 710.

Details

Redox score ?
81
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
36
Peptide accession
Q571K4
Residue number A
693
Residue number B
710
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 693 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 710 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 693 and 696.

Details

Redox score ?
77
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
48
Peptide accession
Q571K4
Residue number A
693
Residue number B
696
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 693 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 696 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 between cysteines 696 and 710.

Details

Redox score ?
70
PDB code
3a9k
Structure name
crystal structure of the mouse tab3-nzf in complex with lys63-linked di-ubiquitin
Structure deposition date
2009-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
48
Peptide accession
Q571K4
Residue number A
696
Residue number B
710
Peptide name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Ligandability

Cysteine 696 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 710 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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