ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

IGL@ protein

Intermolecular
Cysteine 245 of Ig-like domain-containing protein and cysteine 232
Intramolecular
Cysteine 41 and cysteine 106
Cysteine 155 and cysteine 214
A redox-regulated disulphide may form between cysteine 245 of Ig-like domain-containing protein and cysteine 232 of IGL@ protein (211 and 212 respectively in this structure).

Details

Redox score ?
93
PDB code
6v8z
Structure name
vrc03 and 10-1074 bound bg505 f14 hiv-1 sosip envelope trimer structure
Structure deposition date
2019-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ig-like domain-containing protein
Peptide B name
IGL@ protein
Peptide A accession
Q6N089
Peptide B accession
Q8N5F4
Peptide A residue number
245
Peptide B residue number
232

Ligandability

Cysteine 245 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 106 (42 and 107 respectively in this structure).

Details

Redox score ?
79
PDB code
4dag
Structure name
structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site
Structure deposition date
2012-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5F4
Residue number A
41
Residue number B
106
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 155 and 214 (154 and 213 respectively in this structure).

Details

Redox score ?
78
PDB code
4dag
Structure name
structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site
Structure deposition date
2012-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5F4
Residue number A
155
Residue number B
214
Peptide name
IGL@ protein

Ligandability

Cysteine 155 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: