ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CD1A protein

Intramolecular
Cysteine 103 and cysteine 167
Cysteine 207 and cysteine 262
A redox-regulated disulphide may form within CD1A protein between cysteines 103 and 167 (102 and 166 respectively in this structure).

Details

Redox score ?
85
PDB code
6nux
Structure name
cd1a-lipid binary complex
Structure deposition date
2019-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5T0
Residue number A
103
Residue number B
167
Peptide name
CD1A protein

Ligandability

Cysteine 103 of CD1A protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of CD1A protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD1A protein between cysteines 207 and 262 (206 and 261 respectively in this structure).

Details

Redox score ?
80
PDB code
6nux
Structure name
cd1a-lipid binary complex
Structure deposition date
2019-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N5T0
Residue number A
207
Residue number B
262
Peptide name
CD1A protein

Ligandability

Cysteine 207 of CD1A protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of CD1A protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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