a tool for identifying drug-targetable redox-active disulphides

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Intermolecular

Cysteine 122 and cysteine 122

A redox-regulated disulphide may form between two units of Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial at cysteines 122 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

31

PDB code

Structure name

kynurenine aminotransferase ii inhibitors

Structure deposition date

2012-08-01

Thiol separation (Å)

9

Half-sphere exposure sum ?

75

Minimum pK_a ?

11

% buried

100

Peptide A name

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Peptide B name

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

122

Peptide B residue number

122

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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