ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Inactive dipeptidyl peptidase 10

Intramolecular
Cysteine 349 and cysteine 356
Cysteine 465 and cysteine 468
Cysteine 475 and cysteine 493
Cysteine 670 and cysteine 780
A redox-regulated disulphide may form within Inactive dipeptidyl peptidase 10 between cysteines 349 and 356.

Details

Redox score ?
86
PDB code
4wjl
Structure name
structure of human dipeptidyl peptidase 10 (dppy): a modulator of neuronal kv4 channels
Structure deposition date
2014-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N608
Residue number A
349
Residue number B
356
Peptide name
Inactive dipeptidyl peptidase 10

Ligandability

Cysteine 349 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive dipeptidyl peptidase 10 between cysteines 465 and 468.

Details

Redox score ?
86
PDB code
4wjl
Structure name
structure of human dipeptidyl peptidase 10 (dppy): a modulator of neuronal kv4 channels
Structure deposition date
2014-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N608
Residue number A
465
Residue number B
468
Peptide name
Inactive dipeptidyl peptidase 10

Ligandability

Cysteine 465 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 468 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive dipeptidyl peptidase 10 between cysteines 475 and 493.

Details

Redox score ?
83
PDB code
4wjl
Structure name
structure of human dipeptidyl peptidase 10 (dppy): a modulator of neuronal kv4 channels
Structure deposition date
2014-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N608
Residue number A
475
Residue number B
493
Peptide name
Inactive dipeptidyl peptidase 10

Ligandability

Cysteine 475 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 493 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive dipeptidyl peptidase 10 between cysteines 670 and 780.

Details

Redox score ?
81
PDB code
4wjl
Structure name
structure of human dipeptidyl peptidase 10 (dppy): a modulator of neuronal kv4 channels
Structure deposition date
2014-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N608
Residue number A
670
Residue number B
780
Peptide name
Inactive dipeptidyl peptidase 10

Ligandability

Cysteine 670 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 780 of Inactive dipeptidyl peptidase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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