a tool for identifying drug-targetable redox-active disulphides

Claudin-19

Intramolecular

Cysteine 54 and cysteine 64

A redox-regulated disulphide may form within Claudin-19 between cysteines 54 and 64.

Details

Redox score ?

84

PDB code

Structure name

crystal structure of mouse claudin-19 in complex with c-terminal fragment of clostridium perfringens enterotoxin

Structure deposition date

2014-12-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

55

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

54

Residue number B

64

Peptide name

Claudin-19

Ligandability

Cysteine 54 of Claudin-19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Claudin-19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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