ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-22 receptor subunit alpha-1

Intramolecular
Cysteine 128 and cysteine 217
Cysteine 71 and cysteine 79
A redox-regulated disulphide may form within Interleukin-22 receptor subunit alpha-1 between cysteines 128 and 217.

Details

Redox score ?
85
PDB code
3dgc
Structure name
structure of il-22/il-22r1
Structure deposition date
2008-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB22
Residue number A
128
Residue number B
217
Peptide name
Interleukin-22 receptor subunit alpha-1

Ligandability

Cysteine 128 of Interleukin-22 receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Interleukin-22 receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-22 receptor subunit alpha-1 between cysteines 71 and 79.

Details

Redox score ?
82
PDB code
6df3
Structure name
crystal structure of ternary complex of il-24 with soluble receptors il-22ra and il-20rb
Structure deposition date
2018-05-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
48
Peptide accession
Q8N6P7
Residue number A
71
Residue number B
79
Peptide name
Interleukin-22 receptor subunit alpha-1

Ligandability

Cysteine 71 of Interleukin-22 receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Interleukin-22 receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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