ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ER membrane protein complex subunit 1

Intramolecular
Cysteine 338 and cysteine 368
Cysteine 227 and cysteine 237
A redox-regulated disulphide may form within ER membrane protein complex subunit 1 between cysteines 338 and 368.

Details

Redox score ?
87
PDB code
6ww7
Structure name
structure of the human er membrane protein complex in a lipid nanodisc
Structure deposition date
2020-05-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N766
Residue number A
338
Residue number B
368
Peptide name
ER membrane protein complex subunit 1

Ligandability

Cysteine 338 of ER membrane protein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 368 of ER membrane protein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ER membrane protein complex subunit 1 between cysteines 227 and 237.

Details

Redox score ?
78
PDB code
7adp
Structure name
cryo-em structure of human er membrane protein complex in gdn detergent
Structure deposition date
2020-09-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8N766
Residue number A
227
Residue number B
237
Peptide name
ER membrane protein complex subunit 1

Ligandability

Cysteine 227 of ER membrane protein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of ER membrane protein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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