ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tubulin polyglutamylase TTLL6

Intermolecular
Cysteine 259 and cysteine 179
Intramolecular
Cysteine 173 and cysteine 201
Cysteine 329 and cysteine 339
Cysteine 227 and cysteine 339
Cysteine 227 and cysteine 329
A redox-regulated disulphide may form between two units of Tubulin polyglutamylase TTLL6 at cysteines 259 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6vzt
Structure name
ttll6 bound to atp
Structure deposition date
2020-02-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
74
Peptide A name
Tubulin polyglutamylase TTLL6
Peptide B name
Tubulin polyglutamylase TTLL6
Peptide A accession
A4Q9E8
Peptide B accession
A4Q9E8
Peptide A residue number
259
Peptide B residue number
179

Ligandability

Cysteine 259 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin polyglutamylase TTLL6 between cysteines 173 and 201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6vzw
Structure name
ttll6 bound to the initiation analog
Structure deposition date
2020-02-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
14
% buried
100
Peptide accession
A4Q9E8
Residue number A
173
Residue number B
201
Peptide name
Tubulin polyglutamylase TTLL6

Ligandability

Cysteine 173 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin polyglutamylase TTLL6 between cysteines 329 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6vzw
Structure name
ttll6 bound to the initiation analog
Structure deposition date
2020-02-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
60
Peptide accession
A4Q9E8
Residue number A
329
Residue number B
339
Peptide name
Tubulin polyglutamylase TTLL6

Ligandability

Cysteine 329 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin polyglutamylase TTLL6 between cysteines 227 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6vzw
Structure name
ttll6 bound to the initiation analog
Structure deposition date
2020-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
94
Peptide accession
A4Q9E8
Residue number A
227
Residue number B
339
Peptide name
Tubulin polyglutamylase TTLL6

Ligandability

Cysteine 227 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin polyglutamylase TTLL6 between cysteines 227 and 329. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6vzw
Structure name
ttll6 bound to the initiation analog
Structure deposition date
2020-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
54
Peptide accession
A4Q9E8
Residue number A
227
Residue number B
329
Peptide name
Tubulin polyglutamylase TTLL6

Ligandability

Cysteine 227 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of Tubulin polyglutamylase TTLL6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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