ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Prostaglandin reductase 2

Intramolecular
Cysteine 187 and cysteine 193
Cysteine 167 and cysteine 253
A redox-regulated disulphide may form within Prostaglandin reductase 2 between cysteines 187 and 193.

Details

Redox score ?
79
PDB code
2vna
Structure name
structure of human zinc-binding alcohol dehydrogenase 1 (zadh1)
Structure deposition date
2008-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
61
Peptide accession
Q8N8N7
Residue number A
187
Residue number B
193
Peptide name
Prostaglandin reductase 2

Ligandability

Cysteine 187 of Prostaglandin reductase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Prostaglandin reductase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prostaglandin reductase 2 between cysteines 167 and 253.

Details

Redox score ?
63
PDB code
2w98
Structure name
crystal structure of human zinc-binding alcohol dehydrogenase 1 (zadh1) in ternary complex with nadp and phenylbutazone
Structure deposition date
2009-01-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
100
Peptide accession
Q8N8N7
Residue number A
167
Residue number B
253
Peptide name
Prostaglandin reductase 2

Ligandability

Cysteine 167 of Prostaglandin reductase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Prostaglandin reductase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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