ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Endonuclease V

Intramolecular
Cysteine 225 and cysteine 228
Cysteine 225 and cysteine 226
Cysteine 226 and cysteine 227
Cysteine 227 and cysteine 228
Cysteine 64 and cysteine 242
Cysteine 225 and cysteine 227
Cysteine 226 and cysteine 228
Cysteine 140 and cysteine 150
A redox-regulated disulphide may form within Endonuclease V between cysteines 225 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
68
Peptide accession
Q8N8Q3
Residue number A
225
Residue number B
228
Peptide name
Endonuclease V

Ligandability

Cysteine 225 of Endonuclease V

Cysteine 228 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 225 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
52
Peptide accession
Q8N8Q3
Residue number A
225
Residue number B
226
Peptide name
Endonuclease V

Ligandability

Cysteine 225 of Endonuclease V

Cysteine 226 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 226 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
76
Peptide accession
Q8N8Q3
Residue number A
226
Residue number B
227
Peptide name
Endonuclease V

Ligandability

Cysteine 226 of Endonuclease V

Cysteine 227 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 227 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
92
Peptide accession
Q8N8Q3
Residue number A
227
Residue number B
228
Peptide name
Endonuclease V

Ligandability

Cysteine 227 of Endonuclease V

Cysteine 228 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 64 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
42
Peptide accession
Q8N8Q3
Residue number A
64
Residue number B
242
Peptide name
Endonuclease V

Ligandability

Cysteine 64 of Endonuclease V

Cysteine 242 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 225 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
76
Peptide accession
Q8N8Q3
Residue number A
225
Residue number B
227
Peptide name
Endonuclease V

Ligandability

Cysteine 225 of Endonuclease V

Cysteine 227 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 226 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
68
Peptide accession
Q8N8Q3
Residue number A
226
Residue number B
228
Peptide name
Endonuclease V

Ligandability

Cysteine 226 of Endonuclease V

Cysteine 228 of Endonuclease V

A redox-regulated disulphide may form within Endonuclease V between cysteines 140 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4nsp
Structure name
crystal structure of human endov
Structure deposition date
2013-11-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
102
Minimum pKa ?
13
% buried
100
Peptide accession
Q8N8Q3
Residue number A
140
Residue number B
150
Peptide name
Endonuclease V

Ligandability

Cysteine 140 of Endonuclease V

Cysteine 150 of Endonuclease V

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