ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Centrosomal protein of 120 kDa

Intramolecular
Cysteine 455 and cysteine 572
Cysteine 455 and cysteine 510
A redox-regulated disulphide may form within Centrosomal protein of 120 kDa between cysteines 455 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6flk
Structure name
crystal structure of cep120 c2c domain
Structure deposition date
2018-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
30
Peptide accession
Q8N960
Residue number A
455
Residue number B
572
Peptide name
Centrosomal protein of 120 kDa

Ligandability

Cysteine 455 of Centrosomal protein of 120 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Centrosomal protein of 120 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 120 kDa between cysteines 455 and 510. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6flk
Structure name
crystal structure of cep120 c2c domain
Structure deposition date
2018-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
38
Peptide accession
Q8N960
Residue number A
455
Residue number B
510
Peptide name
Centrosomal protein of 120 kDa

Ligandability

Cysteine 455 of Centrosomal protein of 120 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Centrosomal protein of 120 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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