ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

39S ribosomal protein L43, mitochondrial

Intramolecular
Cysteine 70 and cysteine 71
Cysteine 71 and cysteine 91
A redox-regulated disulphide may form within 39S ribosomal protein L43, mitochondrial between cysteines 70 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7oia
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3c
Structure deposition date
2021-05-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
10
% buried
79
Peptide accession
Q8N983
Residue number A
70
Residue number B
71
Peptide name
39S ribosomal protein L43, mitochondrial

Ligandability

Cysteine 70 of 39S ribosomal protein L43, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of 39S ribosomal protein L43, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L43, mitochondrial between cysteines 71 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7oib
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3d
Structure deposition date
2021-05-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
11
% buried
72
Peptide accession
Q8N983
Residue number A
71
Residue number B
91
Peptide name
39S ribosomal protein L43, mitochondrial

Ligandability

Cysteine 71 of 39S ribosomal protein L43, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of 39S ribosomal protein L43, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: