ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Sodium-dependent lysophosphatidylcholine symporter 1

Intramolecular
Cysteine 225 and cysteine 473
Cysteine 116 and cysteine 173
Cysteine 43 and cysteine 47
A redox-regulated disulphide may form within Sodium-dependent lysophosphatidylcholine symporter 1 between cysteines 225 and 473 (212 and 460 respectively in this structure).

Details

Redox score ?
85
PDB code
7oix
Structure name
structure of thermostable human mfsd2a in complex with thermostable human sync2
Structure deposition date
2021-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NA29
Residue number A
225
Residue number B
473
Peptide name
Sodium-dependent lysophosphatidylcholine symporter 1

Ligandability

Cysteine 225 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium-dependent lysophosphatidylcholine symporter 1 between cysteines 116 and 173 (103 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7oix
Structure name
structure of thermostable human mfsd2a in complex with thermostable human sync2
Structure deposition date
2021-05-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
58
Peptide accession
Q8NA29
Residue number A
116
Residue number B
173
Peptide name
Sodium-dependent lysophosphatidylcholine symporter 1

Ligandability

Cysteine 116 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium-dependent lysophosphatidylcholine symporter 1 between cysteines 43 and 47. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7n98
Structure name
cryo-em structure of mfsd2a
Structure deposition date
2021-06-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
11
Peptide accession
Q9DA75
Residue number A
43
Residue number B
47
Peptide name
Sodium-dependent lysophosphatidylcholine symporter 1

Ligandability

Cysteine 43 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Sodium-dependent lysophosphatidylcholine symporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: