ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Telomere repeats-binding bouquet formation protein 1

Intramolecular
Cysteine 592 and cysteine 618
Cysteine 595 and cysteine 618
Cysteine 592 and cysteine 595
Cysteine 592 and cysteine 614
Cysteine 614 and cysteine 618
Cysteine 595 and cysteine 614
A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 592 and 618.

Details

Redox score ?
82
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
14
Peptide accession
Q8NA31
Residue number A
592
Residue number B
618
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 592 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 595 and 618.

Details

Redox score ?
81
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
20
Peptide accession
Q8NA31
Residue number A
595
Residue number B
618
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 595 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 592 and 595.

Details

Redox score ?
75
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
11
Peptide accession
Q8NA31
Residue number A
592
Residue number B
595
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 592 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 592 and 614.

Details

Redox score ?
74
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
2
Peptide accession
Q8NA31
Residue number A
592
Residue number B
614
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 592 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 614 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 614 and 618. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
11
Peptide accession
Q8NA31
Residue number A
614
Residue number B
618
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 614 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomere repeats-binding bouquet formation protein 1 between cysteines 595 and 614. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6j07
Structure name
crystal structure of human terb2 and terb1
Structure deposition date
2018-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
8
Peptide accession
Q8NA31
Residue number A
595
Residue number B
614
Peptide name
Telomere repeats-binding bouquet formation protein 1

Ligandability

Cysteine 595 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 614 of Telomere repeats-binding bouquet formation protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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