ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger and BTB domain-containing protein 38

Intramolecular
Cysteine 1040 and cysteine 1043
Cysteine 1012 and cysteine 1015
Cysteine 1068 and cysteine 1071
Cysteine 1096 and cysteine 1099
Cysteine 1012 and cysteine 1031
Cysteine 1040 and cysteine 1046
Cysteine 1015 and cysteine 1031
Cysteine 1043 and cysteine 1046
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1040 and 1043.

Details

Redox score ?
88
PDB code
6e94
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
0
Peptide accession
Q8NAP3
Residue number A
1040
Residue number B
1043
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1040 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1043 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1012 and 1015.

Details

Redox score ?
87
PDB code
6e93
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
7
% buried
0
Peptide accession
Q8NAP3
Residue number A
1012
Residue number B
1015
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1012 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1015 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1068 and 1071.

Details

Redox score ?
86
PDB code
6e94
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
0
Peptide accession
Q8NAP3
Residue number A
1068
Residue number B
1071
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1068 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1071 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1096 and 1099.

Details

Redox score ?
84
PDB code
6e94
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
8
% buried
0
Peptide accession
Q8NAP3
Residue number A
1096
Residue number B
1099
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1096 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1099 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1012 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6e94
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
20
Peptide accession
Q8NAP3
Residue number A
1012
Residue number B
1031
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1012 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1040 and 1046. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6e94
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
0
Peptide accession
Q8NAP3
Residue number A
1040
Residue number B
1046
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1040 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1046 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1015 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6e93
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
32
Minimum pKa ?
8
% buried
20
Peptide accession
Q8NAP3
Residue number A
1015
Residue number B
1031
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1015 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 38 between cysteines 1043 and 1046. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6e93
Structure name
crystal structure of zbtb38 c-terminal zinc fingers 6-9 in complex with methylated dna
Structure deposition date
2018-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
0
Peptide accession
Q8NAP3
Residue number A
1043
Residue number B
1046
Peptide name
Zinc finger and BTB domain-containing protein 38

Ligandability

Cysteine 1043 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1046 of Zinc finger and BTB domain-containing protein 38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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