ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Intramolecular
Cysteine 490 and cysteine 578
Cysteine 69 and cysteine 79
Cysteine 436 and cysteine 437
Cysteine 85 and cysteine 228
A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 between cysteines 490 and 578.

Details

Redox score ?
87
PDB code
6xi2
Structure name
apo form of pomgnt2
Structure deposition date
2020-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NAT1
Residue number A
490
Residue number B
578
Peptide name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Ligandability

Cysteine 490 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 between cysteines 69 and 79.

Details

Redox score ?
86
PDB code
6xfi
Structure name
crystal structures of beta-1,4-n-acetylglucosaminyltransferase 2 (pomgnt2): structural basis for inherited muscular dystrophies
Structure deposition date
2020-06-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NAT1
Residue number A
69
Residue number B
79
Peptide name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Ligandability

Cysteine 69 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 between cysteines 436 and 437.

Details

Redox score ?
86
PDB code
7e9k
Structure name
crystal structure of pomgnt2 in complex with udp and mono-mannosyl peptide (379man long peptide)
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5NDF2
Residue number A
436
Residue number B
437
Peptide name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Ligandability

Cysteine 436 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 between cysteines 85 and 228.

Details

Redox score ?
80
PDB code
6xi2
Structure name
apo form of pomgnt2
Structure deposition date
2020-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NAT1
Residue number A
85
Residue number B
228
Peptide name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Ligandability

Cysteine 85 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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