Lysine-specific histone demethylase 2
Intermolecular
Cysteine 278 and cysteine 278
Cysteine 278 and cysteine 53
Cysteine 227 and cysteine 227 L
Intramolecular
Cysteine 92 and cysteine 95
Cysteine 142 and cysteine 147
Cysteine 142 and cysteine 169
Cysteine 65 and cysteine 95
Cysteine 147 and cysteine 169
Cysteine 147 and cysteine 185
Cysteine 142 and cysteine 185
More...Cysteine 65 and cysteine 92
Cysteine 73 and cysteine 95
Cysteine 169 and cysteine 185
Cysteine 73 and cysteine 92
Cysteine 65 and cysteine 73
Cysteine 58 and cysteine 87
Cysteine 53 and cysteine 58
Cysteine 278 and cysteine 283
Cysteine 442 and cysteine 451
Cysteine 53 and cysteine 87
4gu0 A 278 C 278
A redox-regulated disulphide may form between two units of Lysine-specific histone demethylase 2 at cysteines 278 and 278.
Details
Redox score ?
80
PDB code
4gu0
Structure name
crystal structure of lsd2 with h3
Structure deposition date
2012-08-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
29
Peptide A name
Lysine-specific histone demethylase 2
Peptide B name
Lysine-specific histone demethylase 2
Peptide A accession
Q8NB78
Peptide B accession
Q8NB78
Peptide A residue number
278
Peptide B residue number
278
Ligandability
4gu1 A 278 B 53
A redox-regulated disulphide may form between two units of Lysine-specific histone demethylase 2 at cysteines 278 and 53. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4gu1
Structure name
crystal structure of lsd2
Structure deposition date
2012-08-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
64
Peptide A name
Lysine-specific histone demethylase 2
Peptide B name
Lysine-specific histone demethylase 2
Peptide A accession
Q8NB78
Peptide B accession
Q8NB78
Peptide A residue number
278
Peptide B residue number
53
Ligandability
Cysteine 278 of Lysine-specific histone demethylase 2
Cysteine 53 of Lysine-specific histone demethylase 2
4gu1 A 227 B 227
A redox-regulated disulphide may form between two units of Lysine-specific histone demethylase 2 at cysteines 227 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
4gu1
Structure name
crystal structure of lsd2
Structure deposition date
2012-08-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
66
Peptide A name
Lysine-specific histone demethylase 2
Peptide B name
Lysine-specific histone demethylase 2
Peptide A accession
Q8NB78
Peptide B accession
Q8NB78
Peptide A residue number
227
Peptide B residue number
227
Ligandability
4gu0 A 92 A 95
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 92 and 95.
Details
Redox score ?
90
PDB code
4gu0
Structure name
crystal structure of lsd2 with h3
Structure deposition date
2012-08-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
1
% buried
64
Peptide accession
Q8NB78
Residue number A
92
Residue number B
95
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 92 of Lysine-specific histone demethylase 2
Cysteine 95 of Lysine-specific histone demethylase 2
4gu1 A 142 A 147
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 142 and 147.
Details
Redox score ?
87
PDB code
4gu1
Structure name
crystal structure of lsd2
Structure deposition date
2012-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
5
Peptide accession
Q8NB78
Residue number A
142
Residue number B
147
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 142 of Lysine-specific histone demethylase 2
Cysteine 147 of Lysine-specific histone demethylase 2
4fwj B 142 B 169
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 142 and 169.
Details
Redox score ?
86
PDB code
4fwj
Structure name
native structure of lsd2/aof1/kdm1b in spacegroup of i222 at 2
Structure deposition date
2012-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
16
Peptide accession
Q8NB78
Residue number A
142
Residue number B
169
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 142 of Lysine-specific histone demethylase 2
Cysteine 169 of Lysine-specific histone demethylase 2
4fwe A 65 A 95
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 65 and 95.
Details
Redox score ?
86
PDB code
4fwe
Structure name
native structure of lsd2 /aof1/kdm1b in spacegroup of c2221 at 2
Structure deposition date
2012-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
2
% buried
66
Peptide accession
Q8NB78
Residue number A
65
Residue number B
95
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 65 of Lysine-specific histone demethylase 2
Cysteine 95 of Lysine-specific histone demethylase 2
4gut A 147 A 169
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 147 and 169.
Details
Redox score ?
86
PDB code
4gut
Structure name
crystal structure of lsd2-npac
Structure deposition date
2012-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
8
Peptide accession
Q8NB78
Residue number A
147
Residue number B
169
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 147 of Lysine-specific histone demethylase 2
Cysteine 169 of Lysine-specific histone demethylase 2
7xe2 A 147 A 185
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 147 and 185.
Details
Redox score ?
84
PDB code
7xe2
Structure name
crystal structure of lsd2 in complex with trans-4-br-pcpa
Structure deposition date
2022-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
4
Peptide accession
Q8NB78
Residue number A
147
Residue number B
185
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 147 of Lysine-specific histone demethylase 2
Cysteine 185 of Lysine-specific histone demethylase 2
4gu0 B 142 B 185
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 142 and 185.
Details
Redox score ?
82
PDB code
4gu0
Structure name
crystal structure of lsd2 with h3
Structure deposition date
2012-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
13
Peptide accession
Q8NB78
Residue number A
142
Residue number B
185
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 142 of Lysine-specific histone demethylase 2
Cysteine 185 of Lysine-specific histone demethylase 2
4fwj B 65 B 92
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 65 and 92.
Details
Redox score ?
82
PDB code
4fwj
Structure name
native structure of lsd2/aof1/kdm1b in spacegroup of i222 at 2
Structure deposition date
2012-07-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
36
Peptide accession
Q8NB78
Residue number A
65
Residue number B
92
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 65 of Lysine-specific histone demethylase 2
Cysteine 92 of Lysine-specific histone demethylase 2
7xe3 B 73 B 95
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 73 and 95.
Details
Redox score ?
80
PDB code
7xe3
Structure name
crystal structure of lsd2 in complex with cis-4-br-2,5-f2-pcpa (s1024)
Structure deposition date
2022-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
nan
Peptide accession
Q8NB78
Residue number A
73
Residue number B
95
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 73 of Lysine-specific histone demethylase 2
Cysteine 95 of Lysine-specific histone demethylase 2
4fwe A 169 A 185
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 169 and 185.
Details
Redox score ?
76
PDB code
4fwe
Structure name
native structure of lsd2 /aof1/kdm1b in spacegroup of c2221 at 2
Structure deposition date
2012-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
12
Peptide accession
Q8NB78
Residue number A
169
Residue number B
185
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 169 of Lysine-specific histone demethylase 2
Cysteine 185 of Lysine-specific histone demethylase 2
4gur A 73 A 92
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 73 and 92.
Details
Redox score ?
75
PDB code
4gur
Structure name
crystal structure of lsd2-npac with h3 in space group p21
Structure deposition date
2012-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
42
Peptide accession
Q8NB78
Residue number A
73
Residue number B
92
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 73 of Lysine-specific histone demethylase 2
Cysteine 92 of Lysine-specific histone demethylase 2
4gu0 C 65 C 73
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 65 and 73.
Details
Redox score ?
75
PDB code
4gu0
Structure name
crystal structure of lsd2 with h3
Structure deposition date
2012-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
50
Peptide accession
Q8NB78
Residue number A
65
Residue number B
73
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 65 of Lysine-specific histone demethylase 2
Cysteine 73 of Lysine-specific histone demethylase 2
7xe3 B 58 B 87
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 58 and 87.
Details
Redox score ?
73
PDB code
7xe3
Structure name
crystal structure of lsd2 in complex with cis-4-br-2,5-f2-pcpa (s1024)
Structure deposition date
2022-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
41
Peptide accession
Q8NB78
Residue number A
58
Residue number B
87
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 58 of Lysine-specific histone demethylase 2
Cysteine 87 of Lysine-specific histone demethylase 2
7xe1 A 53 A 58
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 53 and 58.
Details
Redox score ?
65
PDB code
7xe1
Structure name
crystal structure of lsd2 in complex with cis-4-br-pcpa
Structure deposition date
2022-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
nan
Peptide accession
Q8NB78
Residue number A
53
Residue number B
58
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 53 of Lysine-specific histone demethylase 2
Cysteine 58 of Lysine-specific histone demethylase 2
7xe3 B 278 B 283
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 278 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7xe3
Structure name
crystal structure of lsd2 in complex with cis-4-br-2,5-f2-pcpa (s1024)
Structure deposition date
2022-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
32
Peptide accession
Q8NB78
Residue number A
278
Residue number B
283
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 278 of Lysine-specific histone demethylase 2
Cysteine 283 of Lysine-specific histone demethylase 2
4gu0 B 442 B 451
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 442 and 451. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
4gu0
Structure name
crystal structure of lsd2 with h3
Structure deposition date
2012-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
80
Peptide accession
Q8NB78
Residue number A
442
Residue number B
451
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 442 of Lysine-specific histone demethylase 2
Cysteine 451 of Lysine-specific histone demethylase 2
4gu1 A 53 A 87
A redox-regulated disulphide may form within Lysine-specific histone demethylase 2 between cysteines 53 and 87. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4gu1
Structure name
crystal structure of lsd2
Structure deposition date
2012-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
77
Peptide accession
Q8NB78
Residue number A
53
Residue number B
87
Peptide name
Lysine-specific histone demethylase 2
Ligandability
Cysteine 53 of Lysine-specific histone demethylase 2
Cysteine 87 of Lysine-specific histone demethylase 2
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