ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Xyloside xylosyltransferase 1

Intramolecular
Cysteine 349 and cysteine 374
Cysteine 356 and cysteine 385
A redox-regulated disulphide may form within Xyloside xylosyltransferase 1 between cysteines 349 and 374.

Details

Redox score ?
86
PDB code
4wlz
Structure name
crystal structure of mouse xyloside xylosyltransferase 1 complexed with manganese and udp
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3U4G3
Residue number A
349
Residue number B
374
Peptide name
Xyloside xylosyltransferase 1

Ligandability

Cysteine 349 of Xyloside xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 374 of Xyloside xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xyloside xylosyltransferase 1 between cysteines 356 and 385.

Details

Redox score ?
83
PDB code
4wm0
Structure name
crystal structure of mouse xyloside xylosyltransferase 1 complexed with acceptor ligand
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3U4G3
Residue number A
356
Residue number B
385
Peptide name
Xyloside xylosyltransferase 1

Ligandability

Cysteine 356 of Xyloside xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of Xyloside xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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