ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein O-glucosyltransferase 1

Intramolecular
Cysteine 102 and cysteine 108 L
Cysteine 54 and cysteine 357
Cysteine 263 and cysteine 286
Cysteine 49 and cysteine 56
Cysteine 54 and cysteine 56
Cysteine 49 and cysteine 54
Cysteine 56 and cysteine 357
A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 102 and 108.

Details

Redox score ?
85
PDB code
5l0s
Structure name
human poglut1 in complex with factor vii egf1 and udp
Structure deposition date
2016-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
102
Residue number B
108
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 102 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 54 and 357.

Details

Redox score ?
82
PDB code
5l0u
Structure name
human poglut1 in complex with egf(+) and udp-phosphono-glucose
Structure deposition date
2016-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
54
Residue number B
357
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 54 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 263 and 286.

Details

Redox score ?
80
PDB code
5l0u
Structure name
human poglut1 in complex with egf(+) and udp-phosphono-glucose
Structure deposition date
2016-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
263
Residue number B
286
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 263 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 49 and 56.

Details

Redox score ?
76
PDB code
5ub5
Structure name
human poglut1 in complex with human notch1 egf12 s458t mutant and udp
Structure deposition date
2016-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
23
Peptide accession
Q8NBL1
Residue number A
49
Residue number B
56
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 49 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 54 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5l0u
Structure name
human poglut1 in complex with egf(+) and udp-phosphono-glucose
Structure deposition date
2016-07-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
54
Residue number B
56
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 54 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 49 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5l0u
Structure name
human poglut1 in complex with egf(+) and udp-phosphono-glucose
Structure deposition date
2016-07-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
49
Residue number B
54
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 49 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-glucosyltransferase 1 between cysteines 56 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5ub5
Structure name
human poglut1 in complex with human notch1 egf12 s458t mutant and udp
Structure deposition date
2016-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBL1
Residue number A
56
Residue number B
357
Peptide name
Protein O-glucosyltransferase 1

Ligandability

Cysteine 56 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Protein O-glucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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