ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transmembrane protein 87A

Intramolecular
Cysteine 74 and cysteine 128
Cysteine 89 and cysteine 431
A redox-regulated disulphide may form within Transmembrane protein 87A between cysteines 74 and 128.

Details

Redox score ?
85
PDB code
8ctj
Structure name
cryo-em structure of tmem87a
Structure deposition date
2022-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBN3
Residue number A
74
Residue number B
128
Peptide name
Transmembrane protein 87A

Ligandability

Cysteine 74 of Transmembrane protein 87A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Transmembrane protein 87A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transmembrane protein 87A between cysteines 89 and 431.

Details

Redox score ?
84
PDB code
8ctj
Structure name
cryo-em structure of tmem87a
Structure deposition date
2022-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBN3
Residue number A
89
Residue number B
431
Peptide name
Transmembrane protein 87A

Ligandability

Cysteine 89 of Transmembrane protein 87A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 431 of Transmembrane protein 87A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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