ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Proprotein convertase subtilisin/kexin type 9

Intermolecular
Cysteine 378 and cysteine 318 of Low-density lipoprotein receptor
Intramolecular
Cysteine 534 and cysteine 601
Cysteine 608 and cysteine 679
Cysteine 626 and cysteine 678
Cysteine 552 and cysteine 600
Cysteine 223 and cysteine 255
Cysteine 477 and cysteine 526
Cysteine 635 and cysteine 654
Cysteine 457 and cysteine 527
Cysteine 486 and cysteine 509
More...
Cysteine 323 and cysteine 358
Cysteine 562 and cysteine 588
Cysteine 375 and cysteine 378
Cysteine 552 and cysteine 588
Cysteine 588 and cysteine 600
Cysteine 477 and cysteine 527
Cysteine 626 and cysteine 679
Cysteine 526 and cysteine 527
Cysteine 457 and cysteine 679
Cysteine 678 and cysteine 679
Cysteine 552 and cysteine 601
Cysteine 626 and cysteine 654
Cysteine 601 and cysteine 608
Cysteine 600 and cysteine 601
Cysteine 477 and cysteine 509
Cysteine 527 and cysteine 679
Cysteine 527 and cysteine 534
Cysteine 601 and cysteine 679
Cysteine 608 and cysteine 678
Cysteine 552 and cysteine 562
Cysteine 509 and cysteine 526
Cysteine 608 and cysteine 626
Cysteine 527 and cysteine 601
Cysteine 534 and cysteine 552
Cysteine 552 and cysteine 608
Cysteine 457 and cysteine 626
Cysteine 457 and cysteine 526
Cysteine 626 and cysteine 635
Cysteine 534 and cysteine 600
Cysteine 477 and cysteine 534
A redox-regulated disulphide may form between cysteine 378 of Proprotein convertase subtilisin/kexin type 9 and cysteine 318 of Low-density lipoprotein receptor (378 and 297 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2w2n
Structure name
wt pcsk9-deltac bound to egf-a h306y mutant of ldlr
Structure deposition date
2008-11-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Proprotein convertase subtilisin/kexin type 9
Peptide B name
Low-density lipoprotein receptor
Peptide A accession
Q8NBP7
Peptide B accession
P01130
Peptide A residue number
378
Peptide B residue number
318

Ligandability

Cysteine 378 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Low-density lipoprotein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 534 and 601.

Details

Redox score ?
85
PDB code
7kev
Structure name
pcsk9 in complex with a cyclic peptide ldlr disruptor
Structure deposition date
2020-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
534
Residue number B
601
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 534 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 608 and 679.

Details

Redox score ?
85
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
608
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 608 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 626 and 678.

Details

Redox score ?
84
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
626
Residue number B
678
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 678 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 552 and 600.

Details

Redox score ?
84
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
552
Residue number B
600
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 600 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 223 and 255.

Details

Redox score ?
82
PDB code
6u2f
Structure name
pcsk9-fab 7g7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl- wnlk(hr)igllr - nh2
Structure deposition date
2019-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
223
Residue number B
255
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 223 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 477 and 526.

Details

Redox score ?
82
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
477
Residue number B
526
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 477 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 526 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 635 and 654.

Details

Redox score ?
81
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
635
Residue number B
654
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 635 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 654 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 457 and 527.

Details

Redox score ?
81
PDB code
6u36
Structure name
pcsk9 in complex with a fab and compound 14
Structure deposition date
2019-08-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
457
Residue number B
527
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 457 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 486 and 509.

Details

Redox score ?
80
PDB code
4ne9
Structure name
pcsk9 in complex with ldlr peptide
Structure deposition date
2013-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
486
Residue number B
509
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 486 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 509 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 323 and 358.

Details

Redox score ?
79
PDB code
3p5b
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
323
Residue number B
358
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 323 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 562 and 588.

Details

Redox score ?
77
PDB code
5vlp
Structure name
pcsk9 complex with ldlr antagonist peptide and fab7g7
Structure deposition date
2017-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
562
Residue number B
588
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 562 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 588 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 375 and 378.

Details

Redox score ?
75
PDB code
5vl7
Structure name
pcsk9 complex with fab33
Structure deposition date
2017-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
375
Residue number B
378
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 375 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 378 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 552 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
552
Residue number B
588
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 588 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 588 and 600. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
588
Residue number B
600
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 588 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 600 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 477 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
477
Residue number B
527
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 477 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 626 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
626
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 526 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
526
Residue number B
527
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 526 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 457 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
457
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 457 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 678 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
678
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 678 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 552 and 601. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
552
Residue number B
601
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 626 and 654. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
626
Residue number B
654
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 654 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 601 and 608. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
601
Residue number B
608
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 600 and 601. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
600
Residue number B
601
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 600 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 477 and 509. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
477
Residue number B
509
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 477 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 509 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 527 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
527
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 527 and 534. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
527
Residue number B
534
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 534 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 601 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
601
Residue number B
679
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 608 and 678. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
608
Residue number B
678
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 608 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 678 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 552 and 562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
552
Residue number B
562
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 509 and 526. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
509
Residue number B
526
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 509 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 526 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 608 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
608
Residue number B
626
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 608 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 527 and 601. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
527
Residue number B
601
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 527 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 601 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 534 and 552. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
534
Residue number B
552
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 534 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 552 and 608. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6u3i
Structure name
design of organo-peptides as bipartite pcsk9 antagonists
Structure deposition date
2019-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
552
Residue number B
608
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 552 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 457 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
457
Residue number B
626
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 457 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 457 and 526. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2pmw
Structure name
the crystal structure of proprotein convertase subtilisin kexin type 9 (pcsk9)
Structure deposition date
2007-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5SZQ2
Residue number A
457
Residue number B
526
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 457 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 526 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 626 and 635. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7kfa
Structure name
pcsk9 in complex with pcsk9i a 13mer cyclic peptide ldlr disruptor
Structure deposition date
2020-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
626
Residue number B
635
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 626 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 635 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 534 and 600. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6u38
Structure name
pcsk9 in complex with a fab and compound 8
Structure deposition date
2019-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
534
Residue number B
600
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 534 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 600 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proprotein convertase subtilisin/kexin type 9 between cysteines 477 and 534. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3sqo
Structure name
pcsk9 j16 fab complex
Structure deposition date
2011-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBP7
Residue number A
477
Residue number B
534
Peptide name
Proprotein convertase subtilisin/kexin type 9

Ligandability

Cysteine 477 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 534 of Proprotein convertase subtilisin/kexin type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: