Thioredoxin domain-containing protein 5
Intermolecular
Cysteine 217 and cysteine 248 of Peroxiredoxin-4 L
Intramolecular
Cysteine 217 and cysteine 220 L
Cysteine 350 and cysteine 353 L
Cysteine 247 and cysteine 254
Cysteine 381 and cysteine 388
Cysteine 121 and cysteine 128 L
Cysteine 89 and cysteine 92
Cysteine 220 and cysteine 247 L
Cysteine 92 and cysteine 121 L
Cysteine 353 and cysteine 381 L
More...Cysteine 89 and cysteine 121 L
Cysteine 350 and cysteine 381 L
Cysteine 217 and cysteine 247 L
Cysteine 353 and cysteine 388 L
Cysteine 92 and cysteine 128 L
3wgx B 217 D 298
A redox-regulated disulphide may form between cysteine 217 of Thioredoxin domain-containing protein 5 and cysteine 248 of Peroxiredoxin-4 (217 and 298 respectively in this structure).
Details
Redox score ?
87
PDB code
3wgx
Structure name
crystal structure of erp46 trx2 in a complex with prx4 c-term
Structure deposition date
2013-08-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin domain-containing protein 5
Peptide B name
Peroxiredoxin-4
Peptide A accession
Q8NBS9
Peptide B accession
O08807
Peptide A residue number
217
Peptide B residue number
248
Ligandability
Cysteine 217 of Thioredoxin domain-containing protein 5
Cysteine 248 of Peroxiredoxin-4
3wge A 217 A 220
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 217 and 220.
Details
Redox score ?
87
PDB code
3wge
Structure name
crystal structure of erp46 trx2
Structure deposition date
2013-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
217
Residue number B
220
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 217 of Thioredoxin domain-containing protein 5
Cysteine 220 of Thioredoxin domain-containing protein 5
3uvt B 350 B 353
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 350 and 353.
Details
Redox score ?
85
PDB code
3uvt
Structure name
crystal structure of the third catalytic domain of erp46
Structure deposition date
2011-11-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
29
Peptide accession
Q8NBS9
Residue number A
350
Residue number B
353
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 350 of Thioredoxin domain-containing protein 5
Cysteine 353 of Thioredoxin domain-containing protein 5
3wge A 247 A 254
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 247 and 254.
Details
Redox score ?
84
PDB code
3wge
Structure name
crystal structure of erp46 trx2
Structure deposition date
2013-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
247
Residue number B
254
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 247 of Thioredoxin domain-containing protein 5
Cysteine 254 of Thioredoxin domain-containing protein 5
3uvt A 381 A 388
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 381 and 388.
Details
Redox score ?
84
PDB code
3uvt
Structure name
crystal structure of the third catalytic domain of erp46
Structure deposition date
2011-11-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
381
Residue number B
388
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 381 of Thioredoxin domain-containing protein 5
Cysteine 388 of Thioredoxin domain-containing protein 5
3wgd H 121 H 128
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 121 and 128.
Details
Redox score ?
82
PDB code
3wgd
Structure name
crystal structure of erp46 trx1
Structure deposition date
2013-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
121
Residue number B
128
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 121 of Thioredoxin domain-containing protein 5
Cysteine 128 of Thioredoxin domain-containing protein 5
3wgd B 89 B 92
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 89 and 92.
Details
Redox score ?
79
PDB code
3wgd
Structure name
crystal structure of erp46 trx1
Structure deposition date
2013-08-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
93
Peptide accession
Q8NBS9
Residue number A
89
Residue number B
92
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 89 of Thioredoxin domain-containing protein 5
Cysteine 92 of Thioredoxin domain-containing protein 5
3wge A 220 A 247
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 220 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3wge
Structure name
crystal structure of erp46 trx2
Structure deposition date
2013-08-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
220
Residue number B
247
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 220 of Thioredoxin domain-containing protein 5
Cysteine 247 of Thioredoxin domain-containing protein 5
3wgd A 92 A 121
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 92 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3wgd
Structure name
crystal structure of erp46 trx1
Structure deposition date
2013-08-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
92
Residue number B
121
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 92 of Thioredoxin domain-containing protein 5
Cysteine 121 of Thioredoxin domain-containing protein 5
3uvt C 353 C 381
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 353 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3uvt
Structure name
crystal structure of the third catalytic domain of erp46
Structure deposition date
2011-11-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8NBS9
Residue number A
353
Residue number B
381
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 353 of Thioredoxin domain-containing protein 5
Cysteine 381 of Thioredoxin domain-containing protein 5
3wgd B 89 B 121
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 89 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3wgd
Structure name
crystal structure of erp46 trx1
Structure deposition date
2013-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
7
% buried
nan
Peptide accession
Q8NBS9
Residue number A
89
Residue number B
121
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 89 of Thioredoxin domain-containing protein 5
Cysteine 121 of Thioredoxin domain-containing protein 5
3uvt B 350 B 381
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 350 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3uvt
Structure name
crystal structure of the third catalytic domain of erp46
Structure deposition date
2011-11-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
nan
Peptide accession
Q8NBS9
Residue number A
350
Residue number B
381
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 350 of Thioredoxin domain-containing protein 5
Cysteine 381 of Thioredoxin domain-containing protein 5
3wge A 217 A 247
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 217 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3wge
Structure name
crystal structure of erp46 trx2
Structure deposition date
2013-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NBS9
Residue number A
217
Residue number B
247
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 217 of Thioredoxin domain-containing protein 5
Cysteine 247 of Thioredoxin domain-containing protein 5
2diz A 38 A 73
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 353 and 388 (38 and 73 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2diz
Structure name
the solution structure of the third thioredoxin domain of human thioredoxin domain-containing protein 5
Structure deposition date
2006-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
nan
Peptide accession
Q8NBS9
Residue number A
353
Residue number B
388
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 353 of Thioredoxin domain-containing protein 5
Cysteine 388 of Thioredoxin domain-containing protein 5
3wgd I 92 I 128
A redox-regulated disulphide may form within Thioredoxin domain-containing protein 5 between cysteines 92 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
3wgd
Structure name
crystal structure of erp46 trx1
Structure deposition date
2013-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
12
% buried
nan
Peptide accession
Q8NBS9
Residue number A
92
Residue number B
128
Peptide name
Thioredoxin domain-containing protein 5
Ligandability
Cysteine 92 of Thioredoxin domain-containing protein 5
Cysteine 128 of Thioredoxin domain-containing protein 5
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