ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nitric oxide-associated protein 1

Intramolecular
Cysteine 179 and cysteine 182
Cysteine 364 and cysteine 393
A redox-regulated disulphide may form within Nitric oxide-associated protein 1 between cysteines 179 and 182.

Details

Redox score ?
70
PDB code
8csp
Structure name
human mitochondrial small subunit assembly intermediate (state a)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q8NC60
Residue number A
179
Residue number B
182
Peptide name
Nitric oxide-associated protein 1

Ligandability

Cysteine 179 of Nitric oxide-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Nitric oxide-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nitric oxide-associated protein 1 between cysteines 364 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
8csp
Structure name
human mitochondrial small subunit assembly intermediate (state a)
Structure deposition date
2022-05-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
28
Peptide accession
Q8NC60
Residue number A
364
Residue number B
393
Peptide name
Nitric oxide-associated protein 1

Ligandability

Cysteine 364 of Nitric oxide-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Nitric oxide-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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