Neuropilin and tolloid-like protein 2
Intramolecular
Cysteine 45 and cysteine 72
Cysteine 316 and cysteine 331
Cysteine 177 and cysteine 207
Cysteine 234 and cysteine 256
Cysteine 297 and cysteine 309
Cysteine 304 and cysteine 322
Cysteine 100 and cysteine 122
Cysteine 304 and cysteine 309
Cysteine 297 and cysteine 304
Cysteine 304 and cysteine 316
Cysteine 309 and cysteine 322
7f56 E 45 E 72
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 45 and 72.
Details
Redox score ?
89
PDB code
7f56
Structure name
dnqx-bound gluk2-1xneto2 complex, with asymmetric lbd
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
45
Residue number B
72
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 45 of Neuropilin and tolloid-like protein 2
Cysteine 72 of Neuropilin and tolloid-like protein 2
7f5b E 316 E 331
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 316 and 331.
Details
Redox score ?
88
PDB code
7f5b
Structure name
lbd-tmd focused reconstruction of dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
316
Residue number B
331
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 316 of Neuropilin and tolloid-like protein 2
Cysteine 331 of Neuropilin and tolloid-like protein 2
7f5a E 177 E 207
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 177 and 207.
Details
Redox score ?
88
PDB code
7f5a
Structure name
dnqx-bound gluk2-2xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
177
Residue number B
207
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 177 of Neuropilin and tolloid-like protein 2
Cysteine 207 of Neuropilin and tolloid-like protein 2
7f59 E 234 E 256
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 234 and 256.
Details
Redox score ?
85
PDB code
7f59
Structure name
dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
234
Residue number B
256
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 234 of Neuropilin and tolloid-like protein 2
Cysteine 256 of Neuropilin and tolloid-like protein 2
7f5b E 297 E 309
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 297 and 309.
Details
Redox score ?
82
PDB code
7f5b
Structure name
lbd-tmd focused reconstruction of dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
297
Residue number B
309
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 297 of Neuropilin and tolloid-like protein 2
Cysteine 309 of Neuropilin and tolloid-like protein 2
7f5a F 304 F 322
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 304 and 322.
Details
Redox score ?
81
PDB code
7f5a
Structure name
dnqx-bound gluk2-2xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
304
Residue number B
322
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 304 of Neuropilin and tolloid-like protein 2
Cysteine 322 of Neuropilin and tolloid-like protein 2
7f57 E 100 E 122
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 100 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7f57
Structure name
kainate-bound gluk2-1xneto2 complex, at the desensitized state
Structure deposition date
2021-06-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
39
Peptide accession
C6K2K4
Residue number A
100
Residue number B
122
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 100 of Neuropilin and tolloid-like protein 2
Cysteine 122 of Neuropilin and tolloid-like protein 2
7f5b E 304 E 309
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 304 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7f5b
Structure name
lbd-tmd focused reconstruction of dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
304
Residue number B
309
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 304 of Neuropilin and tolloid-like protein 2
Cysteine 309 of Neuropilin and tolloid-like protein 2
7f59 E 297 E 304
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 297 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7f59
Structure name
dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
297
Residue number B
304
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 297 of Neuropilin and tolloid-like protein 2
Cysteine 304 of Neuropilin and tolloid-like protein 2
7f5a E 304 E 316
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 304 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7f5a
Structure name
dnqx-bound gluk2-2xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
304
Residue number B
316
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 304 of Neuropilin and tolloid-like protein 2
Cysteine 316 of Neuropilin and tolloid-like protein 2
7f5a F 309 F 322
A redox-regulated disulphide may form within Neuropilin and tolloid-like protein 2 between cysteines 309 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7f5a
Structure name
dnqx-bound gluk2-2xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
C6K2K4
Residue number A
309
Residue number B
322
Peptide name
Neuropilin and tolloid-like protein 2
Ligandability
Cysteine 309 of Neuropilin and tolloid-like protein 2
Cysteine 322 of Neuropilin and tolloid-like protein 2
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