ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phospholipase A2 group XV

Intramolecular
Cysteine 65 and cysteine 89
Cysteine 330 and cysteine 371
A redox-regulated disulphide may form within Phospholipase A2 group XV between cysteines 65 and 89 (32 and 56 respectively in this structure).

Details

Redox score ?
83
PDB code
4x95
Structure name
crystal structure of fully glycosylated lysosomal phospholipase a2 in complex with methyl arachidonyl fluorophosphonate (mafp)
Structure deposition date
2014-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCC3
Residue number A
65
Residue number B
89
Peptide name
Phospholipase A2 group XV

Ligandability

Cysteine 65 of Phospholipase A2 group XV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Phospholipase A2 group XV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase A2 group XV between cysteines 330 and 371 (297 and 338 respectively in this structure).

Details

Redox score ?
75
PDB code
4x90
Structure name
crystal structure of lysosomal phospholipase a2
Structure deposition date
2014-12-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
48
Peptide accession
Q8NCC3
Residue number A
330
Residue number B
371
Peptide name
Phospholipase A2 group XV

Ligandability

Cysteine 330 of Phospholipase A2 group XV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 371 of Phospholipase A2 group XV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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