ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytoplasmic dynein 2 heavy chain 1

Intramolecular
Cysteine 2335 and cysteine 2351
Cysteine 1640 and cysteine 1641
Cysteine 2862 and cysteine 3225
Cysteine 3749 and cysteine 3770
Cysteine 4266 and cysteine 4288
Cysteine 1715 and cysteine 1739
Cysteine 4248 and cysteine 4266
Cysteine 3560 and cysteine 3562
Cysteine 2793 and cysteine 2803
A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 2335 and 2351. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
2335
Residue number B
2351
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 2335 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2351 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 1640 and 1641. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
1640
Residue number B
1641
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 1640 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1641 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 2862 and 3225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
2862
Residue number B
3225
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 2862 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 3225 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 3749 and 3770. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
3749
Residue number B
3770
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 3749 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 3770 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 4266 and 4288. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
4266
Residue number B
4288
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 4266 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 4288 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 1715 and 1739. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
1715
Residue number B
1739
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 1715 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1739 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 4248 and 4266. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
4248
Residue number B
4266
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 4248 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 4266 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 3560 and 3562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
3560
Residue number B
3562
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 3560 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 3562 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 2 heavy chain 1 between cysteines 2793 and 2803. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4rh7
Structure name
crystal structure of human cytoplasmic dynein 2 motor domain in complex with adp
Structure deposition date
2014-10-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NCM8
Residue number A
2793
Residue number B
2803
Peptide name
Cytoplasmic dynein 2 heavy chain 1

Ligandability

Cysteine 2793 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2803 of Cytoplasmic dynein 2 heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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